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J Endocrinol 238:R79R94

Growth hormone optimization benefits both sexes, and the peptide doesn't affect sex hormones in ways that create gender-specific concerns

Certainty of evidence Paired reviewers with experience in using GRADE assessed the certainty of evidence independently and resolved discrepancies by discussion

In some cases, such as with vancomycin, a loading or bolus dose of medicine is given before beginning a dosing regimen to more quickly increase the concentration of medication in the blood